In this paper, we describe our approach of using value-sensitive design to guide the design, development, and implementation of health information systems for use in rural areas of two developing countries in Africa. By using shared conceptual investigation, we are able to create a generalized list of stakeholders and values that span multiple projects without losing any of the power of the conceptual investigation. This process can be applied to other projects to develop a stronger set of stakeholders and values. We also present a technical investigation of a vaccine delivery project in Sub-Saharan Africa and plans for an upcoming empirical investigation for a mobile-phone-based support tool for community health workers in East Africa.