Extending Bakhtin's chronotopic theory to the interpretation of nonfictional texts, this article examines the role of narrative conventions in the epistemological development of a health care field. The authors argue that changes marking the emergence of occupational therapy as an autonomous profession illustrate how explanatory narrative frames emerge from and embody assumptions about the world. Taking up pivotal lectures by key figures in this field as material for analysis, the authors demonstrate how biomedical, psychosocial, and dialogic-intersubjective narrative genres frame the dynamics of the therapeutic situation for clinical practitioners and other members of the field. By using chronotopic analysis to understand the narrative-epistemic transformation of academic and professional fields, the authors provide new ways to think about the long-term dialogue between explanatory frameworks in knowledge-making communities.