The role of literary and rhetorical tropes in scientific discourse is frequently overlooked, largely because “rhetoric” and “science” seem to be incompatible modes of expression. However, if we look closely at scientific explanations—especially those designed to inform a general public—we find that they are as reliant on, if not more so, than more “subjective” forms of public discourse. In A Grammar of Motive, Kenneth Burke posits that all forms of discourse rely heavily on the “four master tropes” of metaphor, metonymy, synecdoche, and irony to express ideas, and science is not an exception. This article outlines the processes behind the four master tropes and demonstrates instances where these tropes occur in the expression of scientific concepts found in such fields as biology, physics, and even mathematics. The purpose is to show that, contrary to what many members of the scientific (and lay) community suppose, rhetorical and literary tropes are necessary components to a linguistic understanding of complex scientific concepts; that such tropes do not hinder our understanding, but are in fact necessary to it.