The future of the rhetoric of science—which will increasingly take the form of a rhetoric of technology, science, and medicine (RTSM)—will be shaped by its move away from its modernist, humanistic roots in response to institutional pressures and historical contingencies. This paper advocates a “praxiographical” emphasis on the ability to intervene in science policy and other STEM-related discourses for the field of RTSM. It describes four research foci emerging from this emphasis to be used as areas of programmatic concern at an Institute for Applied Rhetoric of Science and Sustainability at the newly organized Patel College of Global Sustainability at the University of South Florida.