This State of the Inquiry (SotI) critically investigates the implications of generative artificial intelligence (GAI) for interdisciplinary research and scholarly communication within the global English-medium knowledge economy (GEMKE). Anchored in three guiding questions, the article interrogates (1) the extent to which GAI facilitates genuine interdisciplinary knowledge production versus reinforcing entrenched disciplinary silos; (2) how GAI’s dependence on established academic infrastructures influences the visibility and legitimacy of particular interdisciplinary fields; and (3) the impact of automated cross-disciplinary synthesis on the epistemic agency and intellectual labor of human scholars. While GAI holds potential to enhance research efficiency and foster new forms of interdisciplinarity, the outcomes of its integration depend largely on how scholars employ these tools; without critical and contextually informed use, it may contribute to epistemic homogenization and the marginalization of nondominant knowledge systems. The SotI advocates for a critically reflexive and contextually informed approach to the integration of GAI in academic practice, while also recognizing the capacity of scholars—particularly those on the (semi)periphery—to actively shape, adapt, and resist these tools in ways that foster inclusive and transformative interdisciplinary scholarship.