The purpose of this study is to construct and validate a scale of electronic health (e-health) communication competence. Based on a comprehensive review of e-health literature, this scale was constructed using two studies to gather data and validate the scale; four dimensions emerged in the final measurement: e-health self-efficacy, knowledge, usage, and motivation. Results suggest the e-health competence scale is useful for researchers to develop online health interventions and other domains of computer-mediated communication.