Abstract
The coronavirus pandemic has been widely experienced online, and the experience of COVID-19 vaccines is no exception. This article reports on a case study of social media writing authored by COVID-19 vaccine clinical trial participants as a new and innovative form of vaccine communication. Findings offer three insights about vaccine decision-making and communication: 1) vaccine refusal, confidence, and hesitancy are increasingly informed by individuals’ personal assessments of vulnerability and risk; 2) expressed vaccine hesitancy is characterized by openness to persuasion; and 3) this impressionable vaccine hesitancy can be productively addressed in spaces that bridge lived experience and medical expertise. Building on these insights, this article delineates strategies for meaningful and participatory online communication about vaccination.